Showing posts with label Men's health. Show all posts
Showing posts with label Men's health. Show all posts

10/19/2007

FDA: Sudden Hearing Loss Linked To Erectile Dysfunction Drugs

money.cnn.com

The U.S. Food and Drug Administration said Thursday it's approved new erectile dysfunction drug labels to more prominently display the potential risk of sudden hearing loss.

The labeling change - first reported by CNBC - applies to Pfizer Inc.'s (PFE) Viagra, Eli Lilly & Co.'s (LLY) Cialis, Levitra marketed by GlaxoSmithKline PLC (GSK), Schering-Plough Corp. (SGP) and Bayer AG (BAY). The agency said the change will also apply to Pfizer's Revatio, a drug with the same active ingredient as Viagra that's used to treat pulmonary arterial hypertension.

The FDA said it found a total of 29 reports of sudden hearing loss among patients taking the erectile dysfunction drugs. The agency said the search of its adverse-events database was prompted by a case report in medical literature of a patient with sudden hearing loss who was taking Viagra. Such adverse-event reports, which are filed to the FDA by drug companies, doctors and patients, does not mean a particular drug has caused a problem.

The FDA said hearing loss was also reported in a few patients in clinical trials of these drugs. The FDA said in most cases the sudden hearing loss occurred in one ear.

All of the drugs fall into a category of drugs known as PDE5 inhibitors.

"Though no causal relationship has been demonstrated, FDA believed that the strong temporal relationship between the use of PDE5 inhibitors and sudden hearing loss in these cases warranted revisions to the product labeling for the drug class," the FDA said in a statement posted on its Web site.

The agency noted that hearing loss is commonly reported in an aging population, especially in patients with risk factors for erectile dysfunction. "However, sudden hearing loss is an uncommon event at any age," the agency said.

10/16/2007

Sex Every Day is Prescription for Improving Sperm Quality

www.timesonline.co.uk

Men who suffer fertility problems because of low sperm quality may be able to improve their chances of fatherhood by having sex every day, research has suggested.

While those trying for a baby are often told to refrain from ejaculating too often to protect their sperm count, Australian scientists have shown that this can be counterproductive and may lower male fertility.

Among men whose fertility problems stem from genetic damage to their sperm rather than a low sperm count, abstaining from sex can make their difficulties worse, research led by David Greening, of Sydney IVF, has shown.

The pilot study of 42 men whose sperm showed significant DNA damage found that daily ejaculation reduced this by 12 per cent. While the results are preliminary and no direct effect on fertility has yet been measured, they suggest that certain men could benefit from having sex more often, or from abstaining less before providing semen for use in IVF.

Dr Greening, who presented his results at the American Society for Reproductive Medicine conference in Washington yesterday, said: “I’m convinced that ejaculating more frequently, ie daily, improves sperm DNA damage in most men by a decent amount.

“Prior to IVF, for example, men are abstaining a lot more than normal and perhaps sperm DNA increases more than usual. Men think if they abstain for longer times before, say, ovulation that their sperm will be better. [There may be] more volume and numbers but DNA damage may increase.”

Abstaining from sex does increase the number of sperm that are ejaculated, and this has led to advice that couples trying for a baby should have sex every two to three days.

Longer periods of abstinence, however, achieve little because while the quantity of sperm might increase, its quality declines. As sperm is produced, it is stored in the epididymis at the top of the testicle, but the longer it sits there the more damage it accumulates from exposure to free radicals.

Regular ejaculation empties this sperm reservoir, making sure that newly produced sperm of higher genetic quality can get out.

Allan Pacey, a senior lecturer in andrology at the University of Sheffield, said that clearing the reservoir was more important when sperm had high levels of genetic damage. “If you get above 30 to 40 per cent damaged DNA, a man is highly likely to be infertile,” he said. “When you put people on a daily ejaculation regime, it reduces that figure for DNA damage. If you can go from 30 per cent down to 20 per cent that is quite a big shift, that should have implications for fertility.

“There is a trade-off between genetic damage and quantity, so when a couple are first trying to get pregnant a wait of two to three days is probably advisable. But if you are a guy who has high DNA damage and a decent sperm count, it is probably in your interest to ejaculate every day.

“I remember one couple in which the woman would only let the man ejaculate when she was in her fertile period, so the poor chap was going without for almost a month at a time.

“Even leaving aside the frustration that must have caused, it would have had no benefits.”

10/10/2007

Surgery Best For Prostate Cancer Patients

www.dogflu.ca

A new study finds that prostate cancer surgery to remove the entire gland offers the best chance of male patients surviving the disease

A new study confirms that surgery is a really good choice for many men who are diagnosed with prostate cancer.

The study finds that men have the best chance for long term survival if their prostate gland is removed after they are diagnosed with the disease.

For the study Dr. Arnaud Merglen and colleagues at Geneva University in Switzerland studied data from a registry containing 844 men diagnosed with the disease.

They found that within the initial 5 years of treatment the length of survival did not vary that much depending on what form of treatment men received.

But after 10 years, "patients treated with radiotherapy or watchful waiting had a significantly increased risk of death from prostate cancer compared with patients who underwent prostatectomy (removal of the gland)," the study said.

After 10 years, the survival rates were: 83% for prostate gland removal,75% for radiation, 72% for waiting, 41% for hormone therapy and 71% for other forms of treatment.

"There is growing evidence from observational studies that prostatectomy offers the best chance of long-term specific survival in men with localized prostate cancer, in particular younger patients and those with poorly differentiated tumors," the study concluded.

10/08/2007

Study: Sex OK for Men with Chronic Heart Failure

Sex may not be dangerous for men with chronic heart failure, despite fears that intercourse may place too much strain on their heart, a new review shows.

The problem, however, is that many men with chronic heart problems may lose interest in sex as a result of the fatigue, depression, and the prescription side effects they often experience, as well as from fear of damaging the heart, researchers say.

The literature review, published in Mayo Clinic Proceedings, compiled data from patient surveys and clinical trials on chronic heart failure, sexual activity and sexual dysfunction, and found that the patient’s peak heart rate during intercourse was lower than their heart rate during normal everyday activities like walking on level ground, climbing stairs or doing general housework.

Sixty to 70 percent of men with heart conditions also experience erectile dysfunction, the authors said. Erectile dysfunction often results from a decrease in exercise, as well as blood vessel and circulation abnormalities that may reduce blood flow into the penis.

The authors said that patients who cannot take erectile dysfunction medication may be able to remedy the problem by developing an exercise routine, which may help to enhance their sex drives and overall health.

Men with heart failure can have sex

How to Improve Sexual Performance

10/01/2007

Contraception: Progress Brings Hope For New Methods For Men

www.sciencedaily.com

But will men actually use a new method if researchers make one? Elaine Lissner, director of the nonprofit Male Contraception Information Project, says demand is the least of the problems. "You'll never have all men interested, but attitudes have really changed - studies consistently show a majority of men would consider it. You have to remember, between condoms and vasectomy, men in the U.S. are already taking care of a third of contraception. Just imagine if they had another non-permanent option."

New options for male contraceptives: RISUG, IVD, and suspensory method. (Credit: Male Contraception Information Project)Kirsten Thompson, director of the International Male Contraception Coalition, concurs. "Some men are quite desperate for better control over their fertility. They're looking for something they can really count on."

Among the developments announced at the conference:

  • Researchers from the University of Pittsburgh and BIOQUAL Inc. showed they could provide contraception in monkeys with no hormones and no shots needed. (Monkeys are used for studies because of their similarity to humans.) The monkeys had no moving sperm after they took a compound called CDB-4022, and their fertility bounced back completely by 16 weeks. The researchers hope this will be a new nonhormonal contraceptive that can be taken as a pill; in survey results presented at the conference by the International Male Contraception Coalition, 61% of men listed a nonhormonal drug as their first choice. Safety studies will be the next step.
  • A testosterone-like pill ("selective androgen receptor modulator") already in human testing as an osteoporosis and muscle-wasting treatment may have a side benefit: it could work as a hormonal contraceptive that could be taken as a pill. Until now, most "male Pill" research has used a combination of shots, implants, or gels. The SARM's industry support (by GTx, Inc.) gives it a good chance at commercialization.
  • Another androgen that can be taken orally, Dimethandrolone Undecanoate (DMAU), was effective at reducing sperm numbers in rabbits if taken at a low, but not high, dose. Rabbits regained their fertility when they stopped the drug.
  • Makers of the Intra Vas Device are expected to announce effectiveness data showing "substantial equivalence to traditional vasectomy methods" in a study of 90 men. The Intra Vas Device blocks sperm in the vas deferens, the tube sperm swim through that is cut in vasectomy. The set of plugs can be removed if a man changes his mind, and animal studies have shown that fertility returns if it is removed after short-term use. The next step will be to find funding for long-term studies of effectiveness and fertility return.
  • Developers of a home sperm test ("SpermCheck") reported excellent results in men. The test perfectly matched more expensive laboratory tests in detecting whether men's sperm count is above or below 200,000-300,000 per millileter, an extremely low number (normal counts are above 20 million per millileter). When this test hits the market, it will help men who are using "do-it-yourself" methods such as simple wet heat and suspensories. It will also allow men who get vasectomies to know when their sperm are cleared out, without going to the doctor. About 1 in 6 American couples uses vasectomy as a contraceptive method, with more than 500,000 men opting for the procedure each year.

Researchers from around the world are also announcing new targets for contraception, and incremental progress on hormonal approaches ("the male Pill").

Male Birth Control might be on the market soon

Men's Health Zone

9/26/2007

Man's voice an indicator of sexual potency: study

Canadian Research; Men with deep tones produce more children

Tom Blackwell

For many women, the deepness of a man's voice is one of the most powerful aphrodisiacs, a new study co-authored by a Canadian psychologist suggests.

All else being equal, males with lower voices produce more children than their higher-pitched counterparts, concluded the researchers in a search for evolutionary explanations of sexual attraction.

The study looked at Tanzania's Hadza tribesmen, one of the world's few remaining hunter-gatherer societies, because the Hadzas never use birth control, a complicating factor that makes it impossible to do such research elsewhere in the world.

The discovery that the pitch of their voices was a major determinant of how many children they would father underlines the deep-seated roots of the seemingly superficial human trait, said David Feinberg, a psychology professor at Mc-Master University in Hamilton, Ont.

Previous research has indicated that a deep voice signifies robust genes, in evolutionary terms. The findings, however, can not really be put into action on the dating scene, stressed Prof. Feinberg, a co-author of the study.

"This doesn't mean, go out and find a guy with a low-pitched voice if you want to have lots of babies," he said. "[But] it tells us a bit about where we came from and where we're going."

The findings, though, came as no surprise yesterday to professionals in the dating world.

At Toronto-based Misty River Introductions, billed as a "traditional match-maker," men with deep voices always seem to do better, and are much more likely to move beyond the initial stage of a telephone conversation with their potential date, said manager Linda Miller.

"We've had certain clients, you couldn't tell if they were men or women when they called in. They don't do terribly well," she said. "And then you have men who have radio-annnouncer voices, they have that great masculine timbre, and every call is a hit."

Some of Ruth Claramunt's female clients at Hearts Canada, another match-making service, have actually specified that they like men with low voices.

"Or if someone has a squeaky little voice: 'Oh, I didn't really like him,' " said Ms. Claramunt. "They could be a great big hunky guy and if they have a squeaky voice over the phone, it's sort of a negative."

Prof. Feinberg said he has been trying to see whether human males attract their mates with the same kind of "ornaments," like a peacock's plumage or a deer's antlers, seen elsewhere in the animal world.

Earlier in human evolution, it appears that the appeal of a deep voice was linked to testosterone levels. Deep voices are caused by high testosterone levels in adolescent. Large volumes of the hormone can also prompt immune suppression in a weaker person, so someone who survived to manhood with a deep voice would necessarily have a strong genetic makeup, said the psychologist.

No one, however, has been able to test until now whether the attraction of a deep male voice translated into their having more reproductive success.

For the study, Prof. Feinberg and his colleagues, anthropologists at Harvard and Florida State Universities, looked at 49 men and 42 women among the 1,000-strong Hadza people, who choose their own mates but have a fairly high divorce rate in an informal system of "serial monogamy."

The participants spoke into sensitive microphones and had their voices analysed with sophisticated electronic equipment. The pitch of the men's voices accounted for about 42% of the difference in number of children between fathers, the researchers found.

Although other studies have suggested that men are more attracted to women with high voices, the study found that the pitch of the women's voices did not predict how many children they would have.

Women may favor men with deep voices

9/18/2007

Open Meeting on Prostate Cancer at URMC

Prostate cancer is by far the most common cancer for men. One out of every six men will be diagnosed with it.

Rochester resident Sam Thompson was diagnosed with prostate cancer two years ago. By the time he saw his doctor, he had already developed symptoms. That meant his disease was advanced.

So Mr. Thompson elected to have robotic laparoscopic surgery to remove the prostate.

Dr. Jean Joseph said, "We introduced it to the upstate New York area in 2000 and we've been performing it on a regular basis. We perform ten to fourteen surgeries a week."

Though surgeons have made advances in prostate removal, the key to a successful surgery is still early detection. When found early, men with prostate cancer have a 100 percent survival rate.

When it's detected late, treatment must be radical. If the cancer has grown beyond the prostate, surgery and radiation cannot help it. The treatment is then chemotherapy.

African American men are six times more likely to develop prostate cancer than other racial groups. Even though it’s recommended that men over fifty get annual prostate exams, black men are encouraged to get screened earlier.

Though Mr. Thompson's surgery was successful and he's been cancer-free for two years, he regrets he didn't see his doctor sooner.

"For me, I wish I had started at 48, 49,” Thompson said.” Different people react differently. Different nationalities react differently. So if you do it at an early age, 47, 48, you can't go wrong."

The University of Rochester Medical Center is having a day-long men's health seminar Friday, September 21. Local patients will share their experiences with prostate cancer care and doctors will discuss various treatments.

To register for the free event, call 585-275-2838

TO CATCH A KILLER: Hospitals promote prostate cancer screenings, especially for blacks

Natural Help for Good Prostate Health

9/14/2007

Study finds Cialis effective for men with spinal injuries

www.canada.com

Medication triples number of times men can have sexual relations

The impotence pill Cialis appears to work even in men with spinal cord injuries, French researchers said Monday.

Impotence often follows spinal cord injuries. Only about 25 percent of men with such injuries are capable of having sex, Dr. Francois Giuliano and colleagues at the Raymond Poincare Hospital in Garches, France said.

They found that Cialis tripled the number of times the men could have sex.

Their study, funded by Eli Lilly and Co., maker of tadalafil or Cialis, involved 197 men with an average age of 38 in France, Germany, Italy and Spain with spinal cord injuries.

After a one-month waiting period, in which no one got treatment, a questionnaire to assess sexual function found both groups had moderate erectile dysfunction, Giuliano's team reported in the Archives of Neurology.

Then 142 men were assigned to the Cialis group and 44 got a placebo for a 12-week period, taking no more than one pill daily as needed before sexual activity.

After four months, men taking Cialis were successful nearly half the time they attempted intercourse, while men in the placebo group succeeded only 16.8 percent of the time.

Cialis and similar drugs work by increasing blood flow to the genitals.

The researchers said the Cialis study achieved success similar to that found in studies of Pfizer Inc.'s Viagra or sildenafil and Glaxosmithkline Plc's Levitra or vardenafil, all of which improved erections in men with impotence after spinal cord injury.

Erectile Dysfunction Drug Helps Men with Spinal Cord Injury

What are the Causes of Decreased Sexuality?

9/12/2007

Prostate funding levels criticized

calsun.canoe.ca

By BILL KAUFMANN

The province's failure to fund a routine prostate cancer examination is likely increasing the death toll, says a lobbyist battling the disease.

Alberta, along with Ontario, B.C. and Quebec, are the four provinces that don't publicly cover prostate specific antigen blood tests that detect heightened risk of prostate cancer in men, said Greg Sarney of the Prostate Cancer Research Foundation of Canada.

"Encouraging guys to get this test is critical," said Sarney. "Men are good about taking care of their cars and golf clubs, but not so much themselves."

Such screening, along with digital rectal exams, can be extremely effective, with 95% of prostate cancers curable if treated immediately.

Linda MacNaughton of the Prostate Cancer Institute in Calgary said her organization will reimburse men who have paid for the PSA test, which costs around $23.

"Eight men die every week from prostate cancer in Alberta," said MacNaughton, noting Prostate Cancer Awareness Week runs Sept. 17-24.

"I'd love to see every guy at age 40 get the test."

Regular prostate screenings could save your life

Prostate Cancer: Early Detection Saves Lives

Join the Prostacet Club Risk Free Today

9/05/2007

Grape skin extract inhibits prostate cancer cell growth

www.freshplaza.com

Laboratory experiments show that an extract of the skin of muscadine grapes can inhibit growth of prostate cancer cells in the laboratory. Investigators from the National Cancer Institute (NCI), part of the National Institutes of Health, and their research partners also show that muscadine grape skin extract (MSKE) does not contain significant amounts of resveratrol, another grape skin component that has been widely studied and shown to be of potential benefit in preventing prostate cancer growth.

The results appear in the September 1, 2007, issue of Cancer Research.

Using a series of human prostate cancer cells, representing different stages of prostate cancer progression, the researchers showed that MSKE significantly inhibits the growth of cancerous, but not normal, prostate cells, primarily by inducing a process called apoptosis, or programmed cell death.

Programmed cell death is one of the mechanisms the body uses to rid itself of cells with unrepaired genetic damage before those cells can duplicate themselves. In contrast, resveratrol seems to act by blocking the cell cycle, a sequence of steps that a cell passes through when it grows and divides into two identical cells. Both mechanisms are used by the body to prevent the development of cancer.

According to Jeffrey E. Green, M.D., chief of the Transgenic Oncogenesis and Genomics Section in NCI's Center for Cancer Research (CCR), "These results show that MSKE may have potent antitumor activities in the lab that differ from the effects of resveratrol. Further studies of MSKE will be necessary to determine if this extract has potential as a chemopreventive or therapeutic agent."

The fact that all of the cells studied, which cover the different stages of prostate cancer tumor progression, responded to MSKE suggests that the active compounds in this extract may inhibit tumor development at very early stages.

The muscadine grape (Vitis rotundifolia) is distinct from the more common red grapes used to produce red wines, a major source of resveratrol. The chemical constituents of muscadine grapes differ from most other grape varieties, as they are richer in chemicals called anthocyanins. Anthocyanins, which produce the red and purple colors of the grapes, have strong antioxidant activity and have shown several antitumor effects, including inhibition of DNA synthesis in breast cancer cells, of blood vessel growth in some tumors, and of enzymes involved in tumor spread. Muscadine grapes can be found growing wild from Delaware to the Gulf of Mexico and westward from Missouri to Texas.

While previous studies suggested that anthocyanins might suppress the cancer process, no rigorous study of the mechanisms underlying these effects has yet been done. Resveratrol, by contrast, has been widely examined. Although earlier studies showed that it can induce programmed cell death in prostate cancer cells, resveratrol did not significantly induce cell death in the prostate cell model system used for this muscadine study. The results of this study suggest that resveratrol may activate different antitumor mechanisms than MSKE.

Even though MSKE had significant inhibitory effects on the prostate cancer cells studied, it did not alter the growth rate of the normal human prostate cells in the lab, which served as controls. Ongoing studies of MSKE in animals will help to determine the underlying mechanisms of MSKE's inhibitory effects in prostate cancer cells. The researchers hope that the lab effects of MSKE will be reproducible in testing on cancerous and normal prostate cells in animals. Should MSKE move on to trials in humans, Green says that since "muscadine grape products, including grape juice and grape wine, have been used in human studies without reported side effects, they may be relatively safe for use in clinical trials."

Natural Help for Good Prostate Health

Soy Extract Helps Some Prostate Cancer Patients

PakTribune.com

ISLAMABAD: A dietary supplement that contains the soy extract genistein reduced prostate-specific antigen (PSA) levels by as much as 61 percent in men with untreated prostate cancer.

But the dietary supplement didn't have the same effect in men who had undergone surgery, radiation or hormone therapy for prostate cancer, say researchers from the University of California, Davis Cancer Center.

PSA is a blood marker for prostate cancer. An increase is PSA is a warning sign of first-time prostate cancer or a sign of recurrence or progression of the disease in men who have been treated for prostate cancer.

The study included 62 men with prostate cancer and elevated PSA levels. They were given 5 grams a day of genistein concentrated polysaccharide for six months. Sixteen of the men were on watchful waiting for the disease and 46 had undergone surgery, radiation or hormone therapy.

Watchful waiting is recommended for some men with prostate cancer whose cancer causes no symptoms, is expected to grow slowly, and is small and contained within one area of the prostate.

Among the 16 men on watchful waiting, three had to drop out of the study due to diarrhea. Of the 13 who completed the study, eight had a drop in their PSA levels. Those reductions ranged from 3 percent to 61 percent.

The other five in that group had increased PSA levels by the end of the study.

In the group of 46 men who had received treatment, one man had no change in his PSA level and all the rest had increases in PSA.

The study was presented April 30 at the American Urological Association meeting in Chicago.

Join the Prostacet Club Risk Free Today

8/22/2007

Obesity Risk for Prostate Cancer Recurrence, Death

Source: http://www.foxnews.com/

Men who are obese at the time of being diagnosed with prostate cancer are more likely to see the cancer recur and ultimately die from it, according to a new study.

The research, conducted by Seattle's Fred Hutchinson Cancer Research Center and the University of Washington School of Public Health and Community Medicine, included 752 men aged 40-64 who were newly diagnosed with prostate cancer.

In interviews, the men provided their height and weight one year before their diagnosis. Researchers calculated the men's body mass indexes based on the height and weight figures and later compared survival rates to the men's BMIs.

The risk of death and recurrence in obese men was seen regardless of the treatment the men received for the cancer and was the same for men with low- or high-grade cancer.

"I was very surprised by the findings," said study author Dr. Alan Kristal, of the Fred Hutchinson center, in a news release.

Overall, men who had been obese one year before prostate cancer diagnosis were 2.6 times more likely than men with a normal BMI to die of prostate cancer, according to the study, which appears in the journal Cancer. Obesity also tripled the odds that men diagnosed with regional prostate cancer or cancer that had not spread, would see the cancer spread over the course of the year.

If the findings are correct, it could be one more reason for men to reach and maintain a normal weight, but further study is needed, Kristal said.

Prostacet supports healthy prostate function